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All items in the Healthy Skepticism Library

All the 20545 items in the Healthy Skepticism Library are listed below in order of publication date with the most recent at the top. There are 100 items per page.

Page 23 of 206 pages ‹ First  < 21 22 23 24 25 >  Last ›

HSL17302
DTC at the Crossroads: A 'Direct' Hit or Miss?
ims 2010
http://www.imshealth.com/vgn/images/portal/cit_40000873/15/35/58020533DTCBrochure092204.pdf

HSL17315
Gough IR, Dickinson I, Maddern G, Grigg M, Hillis DJ
Winds of change: growing demands for transparency in the relationship between doctors and the pharmaceutical industry
MJA 2010;192:(5):293-295
http://www.mja.com.au/public/issues/192_05_010310/letters_010310_fm-3.html

HSL17316
Pratt IS, Hughes CL, Slevin TJ
Winds of change: growing demands for transparency in the relationship between doctors and the pharmaceutical industry
MJA 2010;192:(5):293-295
http://www.mja.com.au/public/issues/192_05_010310/letters_010310_fm-3.html

HSL17317
Barnes RK.
Winds of change: growing demands for transparency in the relationship between doctors and the pharmaceutical industry
MJA 2010;192:(5):293-295
http://www.mja.com.au/public/issues/192_05_010310/letters_010310_fm-3.html

HSL17494
Vitry A
Reporting of Studies on New Medicines in Major Medical Journals: A Case Study in Breast Cancer
Clinical Pharmacology & Therapeutics 2010;87:(4):398–400
http://www.nature.com/clpt/journal/v87/n4/abs/clpt2009278a.html

HSL17537
Misra S, Ganzini L, Keepers G.
Psychiatric resident and faculty views on and interactions with the pharmaceutical industry.
Acad Psychiatry 2010 Spr;34:(2):102-8
http://ap.psychiatryonline.org/cgi/content/full/34/2/102

HSL17591
Davis JJ
The effect of placement and modality on the recall of information from pharmaceutical web sites
Journal of Medical Marketing 2010;10:(2):99–114 [Epub ahead of print]
http://www.palgrave-journals.com/jmm/journal/v10/n2/abs/jmm200942a.html

HSL17592
Seong Park J, Grow JM
Symptom information in direct-to-consumer antidepressant advertising and college students’ perception of the lifetime risk of depression
Journal of Medical Marketing 2010;10:(2):123–133 [Epub ahead of print]
http://www.palgrave-journals.com/jmm/journal/v10/n2/abs/jmm200944a.html

HSL17602
Pettijohn CE, Rozell, EJ, Newman A
The relationship between emotional intelligence and customer orientation for pharmaceutical salespeople: A UK perspective
International Journal of Pharmaceutical and Healthcare Marketing 2010;4:(1):21 - 39
http://www.emeraldinsight.com/Insight/viewContentItem.do?contentType=Article&contentId=1852702

HSL17695
Saddichha S
Disease Mongering in Psychiatry: Is It Fact or Fiction?
World Medical & Health Policy 2010;2:(1):15
http://www.psocommons.org/wmhp/vol2/iss1/art15

HSL17708
Klemperer D
Drug Research: Marketing Before Evidence, Sales Before Safety
Dtsch Arztebl Int 2010;107:(16):277-8
http://www.aerzteblatt.de/int/article.asp?src=heft&id=74341

HSL17709
Schott G, Pachl H, Limbach U, Gundert-Remy U, Ludwig W, Lieb K
The Financing of Drug Trials by Pharmaceutical Companies and Its Consequences: Part 1. A Qualitative, Systematic Review of the Literature on Possible Influences on the Findings, Protocols, and Quality of Drug Trials
Dtsch Arztebl Int 2010;107:(16):279-85
http://www.aerzteblatt.de/int/article.asp?id=74342

HSL17747
Shankar PR.
Doctors and pharmaceutical promotion.
Pharos Alpha Omega Alpha Honor Med Soc 2010 Spr;73:(2):49
http://www.ncbi.nlm.nih.gov/pubmed/20455380

HSL17748
Orentlicher D.
Prescription data mining and the protection of patients' interests.
J Law Med Ethics 2010 Mar;38:(1):74-84.
http://www3.interscience.wiley.com/journal/123334064/abstract?CRETRY=1&SRETRY=0

HSL17755
Ackerly DC, Glickman SW, Schulman KA.
Economic content in medical journal advertisements for medical devices and prescription drugs.
Pharmacoeconomics 2010;28:(5):429-38
http://adisonline.com/pharmacoeconomics/pages/articleviewer.aspx?year=2010&issue=28050&article=00007&type=abstract

HSL17758
Gostanian A
How the FDA can overturn Wyeth v. Levine
Am J Law Med. 2010;36:(1):248-68.
http://www.ncbi.nlm.nih.gov/pubmed/20481407

HSL17759
Liang BA, Mackey T.
Confronting conflict: addressing institutional conflicts of interest in academic medical centers.
Am J Law Med 2010;36:(1):136-87
http://www.ncbi.nlm.nih.gov/pubmed/20481404

HSL17839
Braillon A
Whistleblowing: Neither reward, nor protection
Journal of Public Health Policy 2010;31:278–279

HSL17927
Clarke PM, Fitzgerald EM
Expiry of patent protection on statins: effects on pharmaceutical expenditure in Australia
eMJA 2010;192:(11):633-636
http://www.mja.com.au/public/issues/192_11_070610/cla11057_fm.html

HSL17977
McGauran N, Wieseler B, Kreis J, Schüler Y-B, Kölsch H, Kaiser T
Reporting bias in medical research - a narrative review
Trials 2010;11:(1):37
http://www.trialsjournal.com/content/pdf/1745-6215-11-37.pdf

HSL18246
Thomadsen BR, Heaton HT 2nd, Jani SK, Masten JP, Napolitano ME, Ouhib Z, Reft CS, Rivard MJ, Robin TT, Subramanian M, Suleiman OH
Off-label use of medical products in radiation therapy: summary of the report of AAPM Task Group No.121
Med Phys 2010;37:(5):2300-11
http://www.ncbi.nlm.nih.gov/pubmed/20527564

HSL18338
Applbaum K
Shadow science: Zyprexa, Eli Lilly and the globalization of pharmaceutical damage control
BioSocieties 2010;5:236-255
http://www.palgrave-journals.com/biosoc/journal/v5/n2/abs/biosoc20105a.html

HSL18386
Bucher HC.
[Benefit and pitfalls in the use of data from surrogate endpoint trials for clinical decision making].
Z Evid Fortbild Qual Gesundhwes 2010;104:(3):230-7;
http://www.ncbi.nlm.nih.gov/pubmed/20608252

HSL18591
Haug JB, Raastad R, Berild D
[Look to Norway - but for how long?]
Tidsskriftet for Den Norske Legeforening 2010;
http://www.tidsskriftet.no/index.php?seks_id=1999673

HSL18661
Kesselheim AS, Outterson K
Fighting Antibiotic Resistance: Marrying New Financial Incentives To Meeting Public Health Goals
Health Affairs 2010;29:(9):1689
http://content.healthaffairs.org/cgi/content/abstract/29/9/1689

HSL18668
Jost TS.
Oversight of marketing relationships between physicians and the drug and device industry: a comparative study.
Am J Law Med 2010;36:(2-3):326-42
http://www.ncbi.nlm.nih.gov/pubmed/20726399

HSL18692
Moynihan R, Mintzes B
Sex, Lies, And Pharmaceuticals: How Drug Companies Plan To Profit From Female Sexual Dysfunction Canada: D&M Publishers Incorporate 2010
http://www.borders.com.au/book/sex-lies-and-pharmaceuticals-how-drug-companies-plan-to-profit-from-female-sexual-dysfunction/8987535/

HSL18723
Fugh-Berman AJ, Scialli AR, Bell AM
Why lunch matters: Assessing physicians' perceptions about industry relationships
Journal of Continuing Education in the Health Professions 2010;30:(3):197-204
http://www.jcehp.com/vol30/3003_berman.asp

HSL18763
The expectations, the reality and the burden of drug donations.
Burnet Instiute 2010
http://www.burnet.edu.au/home/cih/resources/reports

HSL18792
Willis M, Persson U, Zoellner Y, Gradl B.
Reducing uncertainty in value-based pricing using evidence development agreements: the case of continuous intraduodenal infusion of levodopa/carbidopa (duodopa
Appl Health Econ Health Policy 2010;8:(6):377-86
http://content.wkhealth.com/linkback/openurl?issn=1175-5652&volume=8&issue=6&spage=377

HSL18799
Episode 8: Defender of industry-sponsored CME
The Med AD News Show 2010
http://downloads.pharmalive.com/?disp=wpdetail&wpid=c16a5320fa475530d9583c34fd356ef5

HSL18800
Episode 10: Not All Interests Are Conflicts
The Med AD News Show 2010
http://downloads.pharmalive.com/?disp=wpdetail&wpid=e369853df766fa44e1ed0ff613f563bd

HSL18941
Carlat D
Unhinged: The Trouble with Psychiatry - A Doctor's Revelations about a Profession in Crisis : Simon & Schuster 2010
http://books.simonandschuster.com/Unhinged/Daniel-Carlat/9781416590798

HSL18949
Hyer CF
Off-label use and prescribing what does it mean for the foot and ankle surgeon?
Foot Ankle Spec 2010;3:(5):303-6
www.orthofootankle.com

HSL18954
ICH: an exclusive club of drug regulatory agencies and drug companies imposing its rules on the rest of the world.
Prescrire Int. 2010;19:(108):183-6

HSL18970
Kuehlein T, Sghedoni D, Visentin G, Gérvas J, Jamoulle M
Quaternary prevention: a task of the general practitioner
Primary Care 2010;(18):
http://www.primary-care.ch/pdf_d/2010/2010-18/2010-18-368_ELPS_engl.pdf

HSL19398
Ching A, Ishihara M
The effects of detailing on prescribing decisions under quality uncertainty
Quant Mark Econ 2010;8:123–165
http://mpra.ub.uni-muenchen.de/8324/

HSL19261
Chandra, R
Incentives for Global Public Health: Patent Law and Access to Essential Medicines
The role of national laws in reconciling constitutional right to health with TRIPS obligations: an examination of the Glivec patent case in India, Part IV, Chapter 15 Cambridge, UK: Cambridge University Press 2010381-405
http://ebooks.cambridge.org/chapter.jsf?bid=CBO9780511750786&cid=CBO9780511750786A029

HSL19318
Faunce T, Urbas G, Skillen L, Smith M.
Recovering fraudulent claims for Australian federal expenditure on pharmaceuticals and medical devices.
J Law Med 2010;18:(2):302-15
http://www.ncbi.nlm.nih.gov/pubmed/21355432

HSL17928
Parker MH
Normative lessons: codes of conduct, self-regulation and the law
eMJA 2010;192:(11):658-660
http://www.mja.com.au/public/issues/192_11_070610/par10068_fm.html

HSL19709
Jain S
Continuing Medical Education: How to Separate Continuing Medical Education from Pharmaceutical Industry Promotion
Understanding Physician-Pharmaceutical Industry Interactions A Concise Guide Cambridge: Cambridge University Press 2010
http://www.ebooks.cambridge.org/chapter.jsf?bid=CBO9780511665677&cid=CBO9780511665677A013

HSL16987
Barrington KJ
Drug firm conflicting interests: If only industry funded trials were as well done as the WHI
BMJ 2009 Dec 31;339:
http://www.bmj.com/cgi/content/extract/339/dec31_1/b5655

HSL16993
Iskowitz M
Pharma sought safe havens for DTC in '09
Medical Marketing & Media 2009 Dec 31
http://www.mmm-online.com/pharma-sought-safe-havens-for-dtc-in-09/article/160494/

HSL16994
Shankar R
Cervical cancer ad campaign shifted to FM Radio after DCGI's show cause notice to GSK
PharmaBiz.com 2009 Dec 31
http://www.pharmabiz.com/article/detnews.asp?articleid=53336

HSL17069
Mendoza M, Mason M
Solution to killer superbug found in Norway
The Associated Press 2009 Dec 31
http://news.yahoo.com/s/ap/20091231/ap_on_re_us/when_drugs_stop_working_norway_s_answer

HSL17077
Author! Author! Who Should Be Named in a Published Study? An Ethics Case Study
MedScape 2009 Dec 31;
http://cme.medscape.com/qna/preactivity/17033?formid=3&dest_url=http://cme.medscape.com/viewarticle/714405

HSL16984
No Evidence that Additional Price Protection for New Drugs Increased Innovation, Study Finds
2009 Dec 30

HSL16981
Mathew JC
Small drug firms cry foul over ethics code
Business Standard 2009 Dec 27
http://www.business-standard.com/india/news/small-drug-firms-cry-foul-over-ethics-code/380840/

HSL16957
Shankar R
GSK undertakes to withdraw ad on cervical cancer vaccine to DCGI
PharmaBiz.com 2009 Dec 24
http://www.essentialdrugs.org/indiadrug/archive/201001/msg00000.php

HSL16963
Passarella G
Health Plan Loses in Suit Faulting Eli Lilly's Zyprexa Marketing
The Legal Intelligencer 2009 Dec 24
http://www.law.com/jsp/article.jsp?id=1202437268148&Health;_Plan_Loses_in_Suit_Faulting_Eli_Lillys_Zyprexa_Marketing

HSL16974
Fauber J
Journal editor gets royalties as articles favor devices
The Journal Sentinel 2009 Dec 24
http://www.jsonline.com/watchdog/watchdogreports/80036277.html

HSL16964
Whalen J
AstraZeneca Sharpens Focus on Ethics
The Wall Street Journal 2009 Dec 23
http://online.wsj.com/article/SB10001424052748704157304574611724066010600.html

HSL16975
Seaman M
Boston Scientific to pay $22M in payment inquiry
The Associated Press 2009 Dec 23
http://seattletimes.nwsource.com/html/businesstechnology/2010578032_apusbostonscientificsettlement.html

HSL16982
Rosenberg M
New Year's Resolutions for the Drug Industry for 2010
OpEdNews 2009 Dec 23
http://www.opednews.com/articles/New-Year-s-Resolutions-for-by-Martha-Rosenberg-091223-751.html

HSL16947
Silverman E
AstraZeneca Is ‘More Sensitive’ About Illegal Marketing
Pharmalot 2009 Dec 22
http://www.pharmalot.com/2009/12/astrazeneca-is-more-sensitive-about-illegal-marketing/

HSL16961
Grant B
NIH's New Year's resolution?
The Scientist 2009 Dec 22
http://www.the-scientist.com/blog/display/56229/

HSL16962
O’Dowd A
Watchdog criticises drug company for misleading promotional material
BMJ 2009 Dec 22;339:
http://www.bmj.com/cgi/content/extract/339/dec22_2/b5618

HSL16979
Mack J
Shire Implements First Ever Integrated Phone-Assisted Social Network Marketing Campaign for ADHD!
Pharma Marketing Blog 2009 Dec 22
http://pharmamkting.blogspot.com/2009/12/shire-implements-first-ever-integrated.html

HSL16955
Chaudhry P, Stumpf S
The CMO's Role in Curtailing Black-Market Counterfeits
The Advertising Age 2009 Dec 21
http://adage.com/cmostrategy/article?article_id=141187

HSL16956
Spiegel A
How A Bone Disease Grew To Fit The Prescription
npr 2009 Dec 21
http://www.npr.org/templates/story/story.php?storyId=121609815

HSL16945
Hogstrom E
The side effects
The Telegraph Herald 2009 Dec 20
http://www.accessdubuque.com/forums/Comments.cfm?article=267339&MainSection=News%20Stories&newonly=true

HSL16965
Roe S, Jewett C
Tighter rules sought for anti-psychotic drug use in nursing homes
The Chicago Tribune 2009 Dec 20
http://www.chicagotribune.com/health/chi-psychotropics-reformdec20,0,3977364.story

HSL16966
Gerth J
Libel gag on talk of 'medical hurricane'
The Sunday Times 2009 Dec 20
http://business.timesonline.co.uk/tol/business/law/article6962816.ece

HSL16977
Wipatayotin A
Muzzling the drug giants
Bangkok Post 2009 Dec 20
http://www.bangkokpost.com/news/local/29549/muzzling-the-drug-giants

HSL17132
Singer N
Cancer Center Ads Appeal to Emotions at a Fragile Time
The New York Times 2009 Dec 19
http://www.nytimes.com/2009/12/19/health/19cancerads.html?_r=2&th;=&emc=th&pagewanted=all

HSL16948
Silverman E
A Pfizer Whistleblower Tops Business Ethics List
Pharmalot 2009 Dec 18
http://www.pharmalot.com/2009/12/a-pfizer-whistleblower-tops-business-ethics-list/

HSL16959
Camargo Jr KR.
Public health and the knowledge industry.
Rev Saude Publica 2009 Dec 18;
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89102009005000076&lng=en&nrm=iso&tlng=en

HSL17288
Kientop D
Integrating Medical Science Liaisons into Key Account Management
Journal of Medical Marketing 2009 Dec 18;10:(1):45–51
http://www.palgrave-journals.com/jmm/journal/v10/n1/abs/jmm200945a.html

HSL16936
Morris L, Taitsman JK
The Agenda for Continuing Medical Education— Limiting Industry’s Influence
NEJM 2009 Dec 17;361:(25):2478-2482
http://content.nejm.org/cgi/content/short/361/25/2478?query=TOC

HSL16973
Arnold M
AstraZeneca airs
Medical Marketing & Media 2009 Dec 17
http://www.mmm-online.com/astrazeneca-airs-consuming-consumer-for-seroquel-xr-bipolar-depression/article/159860/

HSL16980
A Big Bad Biotech Case and its Effects on Qui Tam
The Qui Tam Team Blog 2009 Dec 17
http://quitamteam.com/blog/big-bad-biotech-case-effects-qui-tam/

HSL17005
Coalition for a Competitive Pharmaceutical Market Runs Ads Stating Congress Is Giving 'Greatest Holiday Gift of All to Brand Pharmaceutical Companies'
Pharmalive 2009 Dec 17
http://pharmalive.com/news/index.cfm?articleID=674501

HSL17007
Harris G
Advisers on Vaccines Often Have Conflicts, Report Says
The New York Times 2009 Dec 17
http://www.nytimes.com/2009/12/18/health/policy/18cdc.html?_r=1

HSL16943
Rasmussen N, Lee K, Bero L.
Association of trial registration with the results and conclusions of published trials of new oncology drugs.
Trials 2009 Dec 16;10:(1):116
http://www.trialsjournal.com/content/10/1/116

HSL16972
Atypical Antipsychotics For Depression: Now With
Clinical Psychology and Psychiatry: A Closer Look 2009 Dec 16
http://clinpsyc.blogspot.com/2009/12/atypical-antipsychotics-for-depression.html

HSL17091
Arnold M
TV viewers suffer risk info overload from pharma ads
Medical Marketing & Media 2009 Dec 16
http://www.mmm-online.com/tv-viewers-suffer-risk-info-overload-from-pharma-ads/article/160480/

HSL16944
Gilheany MF, Borthwick AM.
Recent developments in podiatric prescribing in the UK and Australia.
J Foot Ankle Res 2009 Dec 15;2:(1):37
http://www.jfootankleres.com/content/2/1/37

HSL16949
O’Reilly C, Feeley J
Pfizer Seeks Prempro Video’s Removal From Internet (Update2)
Bloomberg.com 2009 Dec 15
http://www.bloomberg.com/apps/news?pid=20601202&sid=awHcMJRomj_Q

HSL16950
Silverman E
NAMI Runs A Survey On Pharma Funding
Pharmalot 2009 Dec 15
http://www.pharmalot.com/2009/12/nami-runs-a-survey-on-pharma-funding/

HSL16951
Silverman E
Pharma, Conflicts Of Interest And Fingerpointers
Pharmalot 2009 Dec 15
http://www.pharmalot.com/2009/12/pharma-conflicts-of-interest-and-fingerpointers/

HSL16967
Dyer C
Aubrey Blumsohn: Academic who took on industry
BMJ 2009 Dec 15;339:
http://www.bmj.com/cgi/content/short/339/dec15_1/b5293

HSL16976
Treerutkuarkul A
Companies accused of 'pushing' drugs: Doctors back efforts to regulate promotions
Bangkok Post 2009 Dec 15
http://www.bangkokpost.com/news/local/29264/companies-accused-of-pushing-drugs

HSL17008
Edwards J
GSK's $1B Paxil Problem Highlights Murky Disclosures From Euro Drug Companies
BNet 2009 Dec 15
http://industry.bnet.com/pharma/10005807/gsks-1b-paxil-problem-highlights-murky-disclosures-from-euro-drug-companies/

HSL17009
Drug makers quicker to embrace settlements to delay low-cost generics
The San Francisco Business Times 2009 Dec 15
http://www.bizjournals.com/sanfrancisco/stories/2009/12/14/focus1.html?b=1260766800^2567781

HSL16953
Silverman E
Glaxo Publishes List Of Fees Paid To Doctors
Pharmalot 2009 Dec 14
http://www.pharmalot.com/2009/12/glaxo-publishes-list-of-fees-paid-to-doctors/

HSL16954
Feeley J, Cronin Fisk M
Glaxo Said to Have Paid $1 Billion in Paxil Suits (Update2)
Bloomberg.com 2009 Dec 14
http://www.bloomberg.com/apps/news?pid=20601202&sid=aEr_s70bGdYo

HSL16971
Heavey S
UPDATE 1-Drug data mining ban unlikely in Senate health bill
Reuters 2009 Dec 14
http://www.reuters.com/article/idUSN1413386820091215

HSL17049
Aronson JK
Patent medicines and secret remedies
BMJ 2009 Dec 14;
http://www.bmj.com/cgi/content/full/339/dec14_1/b5415

HSL16940
Singer N, Wilson D
Menopause, as Brought to You by Big Pharma
The New York Times 2009 Dec 13
http://www.nytimes.com/2009/12/13/business/13drug.html?_r=1

HSL16941
Singer N
Sure, It’s Treatable. But Is It a Disorder?
The New York Times 2009 Dec 13
http://www.nytimes.com/2009/12/13/business/13stream.html

HSL17289
Hutchings A
Rewarding innovation? An assessment of the factors that affect price and reimbursement status in Europe
Journal of Medical Marketing 2009 Dec 13;10:(1):83–90
http://www.palgrave-journals.com/jmm/journal/v10/n1/abs/jmm200949a.html

HSL16929
HC seeks govt reply on plea against new vaccines
The Times of India 2009 Dec 12
http://timesofindia.indiatimes.com/city/delhi/HC-seeks-govt-reply-on-plea-against-new-vaccines/articleshow/5328812.cms

HSL17342
Pringle E
US Kids Represent Psychiatric Drug Goldmine
truthout 2009 Dec 12
http://www.truthout.org/1213091

HSL16927
Alexander J
Uniform Code on pharma marketing practices ineffective with no binding clause on cos
PharmaBiz.com 2009 Dec 11
http://www.pharmabiz.com/article/detnews.asp?articleid=53032

HSL16928
Perrone M
Sens. move to block drugmakers from mining Rx data
The Associated Press 2009 Dec 11
http://www.rdmag.com/News/FeedsAP/2009/12/life-sciences-sens-move-to-block-drugmakers-from-mining-rx-data/

HSL16931
Shankar P
Privilege motion likely against chemicals minister on Uniform Code for drug marketing
PharmaBiz.com 2009 Dec 11
http://saffron.pharmabiz.com/article/detnews.asp?articleid=53033§ionid=43&z=y

HSL16978
Edwards J
Millions Take Aspirin to Prevent Heart Attacks Based on a Typo; 'Immodest' Bayer Site Not Helping
BNet 2009 Dec 11
http://industry.bnet.com/pharma/10005775/did-a-typo-cause-millions-to-take-aspirin-to-prevent-heart-attacks-immodest-bayer-site-not-helping/

HSL17356
Singh K
Small pharma cos oppose self-regulation for industry, want rules
The Economic Times 2009 Dec 11
http://economictimes.indiatimes.com/news/news-by-industry/healthcare/biotech/pharmaceuticals/Small-pharma-cos-oppose-self-regulation-for-industry-want-rules/articleshow/5324825.cms

HSL17050
Godlee F
We want raw data, now
BMJ 2009 Dec 10;
http://www.bmj.com/cgi/content/full/339/dec10_2/b5405

HSL16917
The Associated Press
EU raids drug makers in antitrust probe
Business Week 2009 Dec 9
http://www.businessweek.com/ap/financialnews/D9CFRRAG0.htm

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What these howls of outrage and hurt amount to is that the medical profession is distressed to find its high opinion of itself not shared by writers of [prescription] drug advertising. It would be a great step forward if doctors stopped bemoaning this attack on their professional maturity and began recognizing how thoroughly justified it is.
- Pierre R. Garai (advertising executive) 1963