Healthy Skepticism Library item: 8679
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Publication type: Journal Article
Finkelstein Y, Rezvani M, Garcia-Bournissen F, Nurmohamed L, Koren G.
Inactive pharmaceutical ingredients : implications for pregnancy.
Can J Clin Pharmacol 2007 Win; 14:(1):e17-28
http://www.cjcp.ca/pdf/CJCP2007_e17_e28.pdf
Abstract:
Administration of pharmaceutical agents to pregnant women is a concern, because of safety issues to both mother and fetus. However, all medication formulations contain any other inactive ingredients in addition to the active drug.
In contrast to the extensive research on the safety of active pharmaceutical ingredients in pregnant patients, the fetal safety of the inactive ingredients has been largely ignored. This is
likely due to the fact that the inactive ingredients are considered to be in “small amounts†and are believed to be “inertâ€. However, this is often not the case. Most pharmaceutical preparations will typically contain 5 to 10 times more inactive ingredients in terms of weight versus the actual active ingredients. Therefore, most tablets, for example, are mainly made up of inactive
ingredients…
Keywords:
Publication Types:
Review
MeSH Terms:
Abnormalities, Drug-Induced/etiology*
Abnormalities, Drug-Induced/prevention & control
Adjuvants, Pharmaceutic/adverse effects*
Adjuvants, Pharmaceutic/classification*
Canada
Drug Compounding*
Drug Labeling
Drug Toxicity
Female
Humans
Lactic Acid/adverse effects
Pharmaceutical Preparations/adverse effects
Phenol/adverse effects
Pregnancy
Pregnancy Complications/drug therapy*
Propylene Glycols/adverse effects
Risk Assessment
Saccharin/adverse effects
Substances:
Adjuvants, Pharmaceutic
Pharmaceutical Preparations
Propylene Glycols
Phenol
Lactic Acid
Saccharin
Notes:
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