Healthy Skepticism Library item: 8674

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Publication type: Journal Article

Jain KK.
Challenges of drug discovery for personalized medicine.
Curr Opin Mol Ther 2006 Dec; 8:(6):487-92
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17243483&query_hl=1&itool=pubmed_DocSum

Abstract:

Personalized medicine—the treatment best suited for an individual patient—is based on genomic as well as other factors that influence the response to drugs. Besides matching existing drugs to appropriate patients, ‘personalization’ is being extended to the drug-discovery stage. Several ‘omics’ technologies are being increasingly used for this purpose and personalized drug-discovery efforts are in progress in major therapeutic areas. Biomarkers are an important link between drug discovery efforts and diagnostics. The concept of personalized medicine is also a driver for the integration of various biotechnologies, such as RNA interference and nanobiotechnology, which are also being applied to drug discovery. The limitations of various approaches to personalized medicine have been identified, as well as the financial implications of fragmenting the markets for drugs for the biopharmaceutical industry, which remains focused on the development of blockbuster drugs.

Keywords:
Publication Types: Review MeSH Terms: Biological Markers Cancer Vaccines/isolation & purification Drug Design* Drug Industry Drug Therapy Epigenesis, Genetic Humans Nanotechnology Neoplasms/therapy Pharmacogenetics Proteomics RNA Interference Systems Biology Substances: Biological Markers Cancer Vaccines