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Healthy Skepticism Library item: 8260

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Steinbrook R.
Guidance for guidelines.
N Engl J Med 2007 Jan 25; 356:(4):331-3
http://content.nejm.org/cgi/content/full/356/4/331


Abstract:

Clinical practice guidelines are systematically developed statements that aim to help physicians and patients reach the best health care decisions. Good guidelines have many attributes, including validity, reliability, reproducibility, clinical applicability and flexibility, clarity, development through a multidisciplinary process, scheduled reviews, and documentation.1 More than 2000 guidelines are currently represented in the National Guideline Clearinghouse (www.guideline.gov). Medical specialty societies are their most common sponsors.

Guidelines rely on both evidence and opinion; they are neither infallible nor a substitute for clinical judgment. They do, however, go beyond systematic reviews to recommend what should and should not be done . . .

Keywords:
MeSH Terms: Advisory Committees* Conflict of Interest*/economics Drug Industry/economics Financial Support Humans Practice Guidelines/standards* United States

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909