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Healthy Skepticism Library item: 7138

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: news

Osteoarthritis: safety concerns over COX-2s will limit uptake
Pharmaceutical Business Review Online 2006 Dec 11
http://www.pharmaceutical-business-review.com/article_researchwire.asp?guid=1C118E2F-B924-4526-85D7-803C4B68D66C


Abstract:

Novartis’ Prexige and Merck’s Arcoxia are COX-2 drugs awaiting FDA approval for osteoarthritis in the US and will face both competition against market leader Celebrex and safety concerns for a share of the NSAID market. Naproxcinod from NicOx is one pipeline drug which could capitalize on these concerns, although none are forecast to reach the blockbuster status held by the COX-2’s prior to Vioxx’s withdrawal. Datamonitor estimates that sales of Prexige will reach $440 million across the seven major markets by 2015. Merck has yet to satisfy the FDA’s demand for the inclusion of naproxen as a comparator drug in safety trials and together with a negative perception of Merck, Arcoxia will only achieve peak sales of $300 million.

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909