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Healthy Skepticism Library item: 6875

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Nathan DG, Weatherall DJ.
Academia and industry: lessons from the unfortunate events in Toronto.
Lancet 1999 Mar 6; 353:(9155):771-2
http://linkinghub.elsevier.com/retrieve/pii/S0140673699000720


Abstract:

The key question in the controversy about deferiprone, Dr. Nancy Olivieri and the drug company Apotex is whether during the course of a drug trial under the auspices of a pharmaceutical company, clinical scientists have the duty to disclose any concerns that they may have about a particular drug to their patients and to the scientific community during the course of the study. There are lessons for the entire biomedical community fromthis unfortunate episode.

Keywords:
*analysis//Canada/deferiprone/Apotex/Hospital for Sick Children/ drug company sponsored research/ bioethics/ guidelines, discussion of/ Research Ethics Boards/ relationship between researchers, academic institutions and industry/ETHICAL ISSUES IN PROMOTION: ETHICS OF TRIALS/SPONSORSHIP: RESEARCH Academic Medical Centers*/legislation & jurisprudence Academic Medical Centers*/trends Clinical Trials/legislation & jurisprudence Drug Industry*/legislation & jurisprudence Drug Industry*/trends Humans Iron Chelating Agents/therapeutic use Ontario Pyridones/therapeutic use Thalassemia/drug therapy

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909