Healthy Skepticism Library item: 6844

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Dieppe P, Chard J, Tallon D, Egger M.
Funding clinical research.
Lancet 1999 May 8; 353:(9164):1626

Abstract:

Industrial sponsorship of a study correlated positively with the likelihood of an outcome in favour of the sponsors’ treatment. The same trend holds true at the level of meta-analyses of clinical trials published in eight high-impact medical journals. Industrial funding of trials has undue influence on the research agenda and distorts the body of published evidence.

Keywords:
*letter to the editor/*analytic survey/clinical trials/ drug company sponsored research/ reporting of results/INFLUENCE OF PROMOTION: OUTCOME OF CLINICAL TRIALS/PROMOTION DISGUISED: CLINICAL TRIALS/SPONSORSHIP: RESEARCH Clinical Trials/economics* Clinical Trials/trends Drug Industry* Female Humans Public Policy Research Support/economics* Research Support/trends

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909