Healthy Skepticism Library item: 5979
Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.
Publication type: Journal Article
Cromer BA, Scholes D, Berenson A, Cundy T, Clark MK, Kaunitz AM; Society for Adolescent Medicine.
Depot medroxyprogesterone acetate and bone mineral density in adolescents--the Black Box Warning: a Position Paper of the Society for Adolescent Medicine.
J Adolesc Health 2006 Aug 01; 39:(2):296-301
http://linkinghub.elsevier.com/retrieve/pii/S1054-139X(06)00098-X
Abstract:
The purpose of this Position Paper is to review the published Black Box Warning regarding depot medroxyprogesterone acetate (DMPA) and bone loss as it relates to adolescent girls. The scientific findings that prompted the Food and Drug Administration to issue the warning are reviewed and the following additional issues are considered: (1) likely low risk of fracture related to DMPA use, (2) evidence of at least partial recovery after discontinuation of the method, and (3) the need to balance the physical, social and economic cost of adolescent pregnancy versus the immediate and long-term impact of DMPA on bone. A list of clinical guidelines is included, the main recommendation of which is to continue prescription of DMPA, with counseling about the risks and benefits, in most of the adolescent population desiring to use this contraceptive method
Keywords:
Adolescent
Adolescent Medicine*
Bone Density/drug effects*
Bone Resorption/chemically induced
Calcium, Dietary
Contraceptive Agents, Female/administration & dosage
Contraceptive Agents, Female/adverse effects*
Contraceptive Agents, Female/contraindications
Counseling
Delayed-Action Preparations
Drug Labeling
Female
Fractures, Bone/etiology
Humans
Medroxyprogesterone 17-Acetate/administration & dosage
Medroxyprogesterone 17-Acetate/adverse effects*
Medroxyprogesterone 17-Acetate/contraindications
Societies, Medical
United States
United States Food and Drug Administration
