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Healthy Skepticism Library item: 537

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

McCarthy M.
Sponsors lose fight to stop thyroxine study publication.
Lancet 1997 Apr 19; 349:(9059):1149
http://www.thelancet.com/search/results?search_searchuri=%2Fsearch%2Fadvanced&search_resulturi=%2Fsearch%2Fresults&search_preview=no&search_reqfirst=1&search_reqcount=20&search_submode=advanced&update_search=no&search_mode=platform&search_cluster=phoenix&search_text1=McCarthy+M&search_within1=au&search_operator1=and&search_text2=Sponsors&search_within2=ti&search_operator2=and&search_text3=&search_within3=all&restrictterm_lancet=lancet&restrictname_lancet=lancet&restricttype_lancet=journal&restrictdesc_lancet=The+Lancet&restrictname_laneur=laneur&restricttype_laneur=journal&restrictdesc_laneur=The+Lancet+Neurology&restrictname_laninf=laninf&restricttype_laninf=journal&restrictdesc_laninf=The+Lancet+Infectious+Diseases&restrictname_lanonc=lanonc&restricttype_lanonc=journal&restrictdesc_lanonc=The+Lancet+Oncology&search_dateradio=combo&search_datecombo=0%3AALL&search_monthstartcombo=1&search_yearstart=1997&search_monthendcombo=12&search_yearend=1997&search_wordsexactly=yes&search_sort=relevance&Submit=Search


Abstract:

Boots Pharmaceuticals, makers of Synthroid (thyroid replacement) contracted with Betty Dong, a researcher at the University of California-San Francisco, to undertake a study to show that generic forms of Synthroid were not bioequivalent to it. When Dong’s study showed otherwise Boots stopped publication of the article and threatened to sue her for contract violation. The campaign to discredit Dong continued after Knoll bought Boots in 1995. Evenually the incident came to light through a front page story in the Wall Street Journal. The study by Dong was finally published in JAMA.

Keywords:
*news story United States drug company sponsored research conflict of interest academic freedom relationship between researchers, academic institutions and industry Betty Dong Boots Knoll ETHICAL ISSUES IN PROMOTION: LINKS BETWEEN HEALTH PROFESSIONALS AND INDUSTRY INFLUENCE OF PROMOTION: PUBLICATION SPONSORSHIP: RESEARCH

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909