Healthy Skepticism Library item: 5351
Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.
Publication type: Journal Article
Nebeker JR, Hoffman JM, Weir CR, Bennett CL, Hurdle JF.
High rates of adverse drug events in a highly computerized hospital.
Arch Intern Med 2005 May 23; 165:(10):1111-6
http://archinte.ama-assn.org/cgi/content/full/165/10/1111
Abstract:
BACKGROUND: Numerous studies have shown that specific computerized interventions may reduce medication errors, but few have examined adverse drug events (ADEs) across all stages of the computerized medication process. We describe the frequency and type of inpatient ADEs that occurred following the adoption of multiple computerized medication ordering and administration systems, including computerized physician order entry (CPOE). METHODS: Using explicit standardized criteria, pharmacists classified inpatient ADEs from prospective daily reviews of electronic medical records from a random sample of all admissions during a 20-week period at a Veterans Administration hospital. We analyzed ADEs that necessitated a changed treatment plan. RESULTS: Among 937 hospital admissions, 483 clinically significant inpatient ADEs were identified, accounting for 52 ADEs per 100 admissions and an incidence density of 70 ADEs per 1000 patient-days. One quarter of the hospitalizations had at least 1 ADE. Of all ADEs, 9% resulted in serious harm, 22% in additional monitoring and interventions, 32% in interventions alone, and 11% in monitoring alone; 27% should have resulted in additional interventions or monitoring. Medication errors contributed to 27% of these ADEs. Errors associated with ADEs occurred in the following stages: 61% ordering, 25% monitoring, 13% administration, 1% dispensing, and 0% transcription. The medical record reflected recognition of 76% of the ADEs. CONCLUSIONS: High rates of ADEs may continue to occur after implementation of CPOE and related computerized medication systems that lack decision support for drug selection, dosing, and monitoring
Keywords:
Clinical Pharmacy Information Systems
Comparative Study
Decision Support Systems, Clinical
Drug Therapy/adverse effects*
Drug Therapy, Computer-Assisted*
Follow-Up Studies
Hospitals, University*
Humans
Medical Records Systems, Computerized*
Medication Errors/statistics & numerical data*
Medication Systems, Hospital
Pharmaceutical Preparations/adverse effects
Random Allocation
Research Support, U.S. Gov't, Non-P.H.S.
Retrospective Studies
