Healthy Skepticism Library item: 5285

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Langton PE, Hankey GJ, Eikelboom JW.
Cardiovascular safety of rofecoxib (Vioxx): lessons learned and unanswered questions: we need processes in place to follow up suspicions about serious adverse events.
Med J Aust 2004 Nov 15; 181:(10):524-5
http://www.mja.com.au/public/issues/181_10_151104/lan10728_fm.html

Keywords:
Cardiovascular Diseases/chemically induced* Cyclooxygenase Inhibitors/adverse effects* Cyclooxygenase Inhibitors/pharmacology Cyclooxygenase Inhibitors/therapeutic use Humans Lactones/adverse effects* Lactones/pharmacology Lactones/therapeutic use Product Surveillance, Postmarketing Risk Assessment Sulfones/adverse effects* Sulfones/pharmacology Sulfones/therapeutic use

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909