Healthy Skepticism Library item: 4946

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Publication type: Journal Article

Sundstrom L, Morrison B 3rd, Bradley M, Pringle A.
Organotypic cultures as tools for functional screening in the CNS.
Drug Discov Today 2005 Jul 15; 10:(14):993-1000
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T64-4GMB0F0-D&_coverDate=07%2F15%2F2005&_alid=406423296&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5020&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c03da4a6b488ecbf4688958874e08133

Abstract:

A major challenge for the pharmaceutical industry is the development of relevant model systems in which knowledge gained from high-throughput, genomic and proteomic approaches can be integrated to study function. Animal models are still the main choice for such studies but over the past few years powerful new in vitro systems have begun to emerge as useful tools to study function. Organotypic cultures made from slices of explanted tissue represent a complex multi-cellular in vitro environment with the potential to assess biological function and are uniquely placed to act as an important link between high-throughput approaches and animal models.

Keywords:
Animals Central Nervous System/growth & development* Central Nervous System/physiology* Drug Industry/methods Drug Industry/trends Technology, Pharmaceutical/methods Technology, Pharmaceutical/trends Tissue Culture Techniques/methods* Tissue Culture Techniques/trends