Healthy Skepticism Library item: 3725

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Epstein RA.
Regulatory paternalism in the market for drugs: lessons from Vioxx and Celebrex.
Yale J Health Policy Law Ethics 2005 Sum; 5:(2):741-70

Keywords:
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Chromans/therapeutic use Clinical Trials Cyclooxygenase Inhibitors/therapeutic use Drug Industry/legislation & jurisprudence* Drug and Narcotic Control/legislation & jurisprudence* Humans Hypoglycemic Agents/therapeutic use Isoxazoles/therapeutic use Lactones/therapeutic use Myocardial Infarction/chemically induced Paternalism* Platelet Aggregation Inhibitors/therapeutic use Pyrazoles/therapeutic use Sulfonamides/therapeutic use Sulfones/therapeutic use Thiazolidinediones/therapeutic use Truth Disclosure* United States United States Food and Drug Administration/legislation & jurisprudence* Vasodilator Agents/therapeutic use

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909