Healthy Skepticism Library item: 238

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Wahlbeck K, Adams C.
Beyond conflict of interest: Sponsored drug trials show more-favourable outcomes.
BMJ 1999 Feb 13; 318:(7181):465

Keywords:
*letter to the editor *analytic survey clozapine drug company sponsored research reporting of results clinical trials INFLUENCE OF PROMOTION: OUTCOME OF CLINICAL TRIALS PROMOTION DISGUISED: CLINICAL TRIALS SPONSORSHIP: RESEARCH

Notes:

Trials comparing clozapine with older antipsychotics in schizophrenic patients were analyzed. Trials sponsored by industry favoured clozapine while nonsponsored trials were equivocal. Sponsored trials reported fewer dropouts for clozapine while nonsponsored trials did not find this.

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909