Healthy Skepticism Library item: 2112

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Publication type: Journal Article

Kaye KI, Welch SA, Graudins LV, Graudins A, Rotem T, Davis SR, Day RO.
Pethidine in emergency departments: promoting evidence-based prescribing.
Med J Aust 2005 Aug 1; 183:(3):129-33
http://www.mja.com.au/public/issues/183_03_010805/kay10502_fm.html

Abstract:

OBJECTIVE: To reduce pethidine prescribing in hospital emergency departments (EDs).

DESIGN: Multi-centre drug use evaluation (DUE) process.

SETTING AND PARTICIPANTS: Emergency departments in 23 public hospitals (22 in New South Wales, 1 in Victoria) from 1 September 2002 to 31 August 2003. Participating hospitals included seven principal referral hospitals, six major non-teaching hospitals and 10 district or community hospitals. Data for comparison were collected from 12 non-participating hospitals.

INTERVENTIONS: Hospital coordinators at each participating hospital were provided with support to implement a range of prescribing interventions in their ED in each of three DUE cycles. Interventions included educational materials (guidelines, posters, prescribing reminders), audit and feedback, and small-group discussions. Three audits of pethidine prescribing were undertaken. Prescribing was compared with evidence-based guidelines and non-concordance identified.

MAIN OUTCOME MEASURES: Number of dosage units of parenteral analgesics issued to the ED from each hospital’s pharmacy department was recorded monthly and aggregated in 3-month periods.

RESULTS: In the 12 months between the preintervention period and the equivalent post-intervention period, pethidine use decreased by 62% in project hospitals (4669 to 1793 units) and 56% in control hospitals (1476 to 648 units). Six months after project completion there was a significantly greater reduction from baseline in participating hospitals (71%; 4669 to 1348 units) compared with non-participating hospitals (64%; 1476 to 532 units; P < 0.001). There was a concurrent increase in use of both morphine and tramadol.

CONCLUSION: There was a sustained reduction in pethidine use during the study period, which may indicate successful promotion of safer analgesic prescribing. It is not clear whether changes were a result of collaborative DUE methods or other factors.