Healthy Skepticism Library item: 1961
Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.
Publication type: Journal Article
Safer DJ.
Design and reporting modifications in industry-sponsored comparative psychopharmacology trials.
J Nerv Ment Dis 2002 Sep; 190:(9):583-92
http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0022-3018&volume=190&issue=9&spage=583
Abstract:
This review of recently published pharmaceutical industry-sponsored comparative psychotropic drug trials aims to classify apparent design and reporting modifications that favor the sponsor’s product. The modifications have been grouped into 13 discrete categories, and representative examples of each are presented. Strong circumstantial evidence suggests that marketing goals led to these adjustments. The consequences of marketing influences on comparative psychopharmacology trials are discussed in terms of conflicts of interest, the integrity of the scientific literature, and costs to consumers, as well as their impact on physician practice.
Keywords:
Clinical Protocols/standards
Clinical Trials/economics
Clinical Trials/methods
Clinical Trials/standards*
Confidentiality
Drug Administration Schedule
Drug Costs/standards
Drug Industry/economics
Drug Industry/methods*
Drug Industry/standards
Duplicate Publication
Fraud
Humans
Mental Disorders/drug therapy
Patient Selection
Periodicals/standards
Physician's Practice Patterns
Psychopharmacology/methods*
Psychopharmacology/organization & administration
Psychotropic Drugs/adverse effects
Psychotropic Drugs/pharmacology
Psychotropic Drugs/therapeutic use
Publication Bias
Research Design/standards*
Research Design/statistics & numerical data
Research Support/economics
Research Support/standards*
Treatment Outcome
