Healthy Skepticism Library item: 1961

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Safer DJ.
Design and reporting modifications in industry-sponsored comparative psychopharmacology trials.
J Nerv Ment Dis 2002 Sep; 190:(9):583-92
http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0022-3018&volume=190&issue=9&spage=583

Abstract:

This review of recently published pharmaceutical industry-sponsored comparative psychotropic drug trials aims to classify apparent design and reporting modifications that favor the sponsor’s product. The modifications have been grouped into 13 discrete categories, and representative examples of each are presented. Strong circumstantial evidence suggests that marketing goals led to these adjustments. The consequences of marketing influences on comparative psychopharmacology trials are discussed in terms of conflicts of interest, the integrity of the scientific literature, and costs to consumers, as well as their impact on physician practice.

Keywords:
Clinical Protocols/standards Clinical Trials/economics Clinical Trials/methods Clinical Trials/standards* Confidentiality Drug Administration Schedule Drug Costs/standards Drug Industry/economics Drug Industry/methods* Drug Industry/standards Duplicate Publication Fraud Humans Mental Disorders/drug therapy Patient Selection Periodicals/standards Physician's Practice Patterns Psychopharmacology/methods* Psychopharmacology/organization & administration Psychotropic Drugs/adverse effects Psychotropic Drugs/pharmacology Psychotropic Drugs/therapeutic use Publication Bias Research Design/standards* Research Design/statistics & numerical data Research Support/economics Research Support/standards* Treatment Outcome