Healthy Skepticism Library item: 1903

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Richards D.
Problems and perils of prescription medicines.
Expert Opin Drug Saf 2003 Sep; 2:(5):509-11
http://www.ncbi.nlm.nih.gov/entrez/utils/lofref.fcgi?PrId=3204&uid=12946251&db=pubmed&url=http://www.ashley-pub.com/doi/abs/10.1517/14740338.2.5.509

Abstract:

Most of the advertising material and articles in scientific journals about new drugs focus on their potential benefits. Data on the safety and tolerability of drugs are collected and carefully analysed during clinical trials, but the scope of this information is limited. Safe use of medicines requires a balanced assessment of both risks and benefits. This symposium at the Royal College of Physicians sought to highlight current issues in assessing the risks associated with prescription medicines. The result was a lively and informative debate with insights and challenges for prescribers and drug developers alike. This report focuses on the issues of most interest to drug developers.

Keywords:
Dose-Response Relationship, Drug Drug Industry Humans Pharmaceutical Preparations/administration & dosage Pharmaceutical Preparations/adverse effects* Pharmaceutical Preparations/economics Pharmacogenetics Prescriptions, Drug Risk Assessment

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909