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Healthy Skepticism Library item: 17412

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: news

Cortez MF
Diabetes Drug Supporters Had Financial Tie to Glaxo, Study Says
Bloomberg News 2010 Mar 19
http://www.bloomberg.com/apps/news?pid=20601124&sid=aM77o8EApL08


Full text:

Most scientists who published articles supporting GlaxoSmithKline Plc’s diabetes drug Avandia after it was linked to heart disease in 2007 had financial ties to the company, according to a Mayo Clinic report.

The Mayo researchers examined more than 200 articles that appeared after an analysis in the New England Journal of Medicine linked Avandia to a 43 percent increased risk of heart attacks, and a subsequent clinical trial found no greater danger of heart disease. Almost 90 percent of scientists who wrote positive articles, reviews or commentaries about Avandia had financial ties to London-based Glaxo, the study published in the British Medical Journal found.

Almost three of every four authors who expressed negative views of the drug had no financial ties to manufacturers of diabetes medicines, while just 6 percent of those with positive opinions of the drug received no funding or fees from industry. The relationships between scientists and pharmaceutical companies may help explain why the interpretations of the published articles varied so widely, the researchers said.

“We aimed to determine whether financial conflicts of interest with pharmaceutical manufacturers could be fuelling this fire,” wrote the researchers, led by Amy Wang, a resident in internal medicine at the Mayo Clinic in Rochester, Minnesota. “From our findings, it appears that the answer is yes.”

Journal Statements

About half the articles carried conflict of interest statements, even though medical journals have beefed up their requirements for disclosing financial links in the past decade, the researchers said.

“These findings, while not necessarily causal, underscore the need for further progress in reporting in order for the scientific record to be trusted,” they said.

A Glaxo spokeswoman said the company posts information and results from all its clinical trials on its Web site.

“It’s vital that people have trust in the way we do research and the way it’s made public,” said Jo Revill, Glaxo spokeswoman, in a telephone interview today. “Part of that is sharing data. What we have done is develop policies that will have disclosure and encourage disclosure.”

Glaxo will disclose all the research payments it makes to investigators and their institutions in the U.S. starting this year, Revill said.

 

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What these howls of outrage and hurt amount to is that the medical profession is distressed to find its high opinion of itself not shared by writers of [prescription] drug advertising. It would be a great step forward if doctors stopped bemoaning this attack on their professional maturity and began recognizing how thoroughly justified it is.
- Pierre R. Garai (advertising executive) 1963