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Healthy Skepticism Library item: 16381

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Moynihan R
Drug Safety: Battle over popular bone drug Fosamax bursts into court
BMJ 2009 08 06;
http://www.bmj.com/cgi/content/extract/339/aug06_1/b3155


Abstract:

A spring evening back in May 1996 was something of a high point for the folks at the global drug company Merck. Three American television networks ran news stories celebrating Merck’s latest blockbuster to fight brittle bones-Fosamax, whose generic name is alendronic acid (or alendronate sodium).

Reporters told tens of millions of viewers that the recently approved drug could cut the risk of a hip fracture in half, and one report described this as “almost miraculous.“1The televangelism proved both efficacious and prophetic: in the years since, the drug became one of Merck’s top selling products, with sales in excess of $3bn (£1.8bn; 2.1bn) annually for several years during the past decade.

Next week, in a district court room not too far away from those same network studios, Merck is scheduled to face the first trial involving its golden goose alendronic acid before Judge John Keenan of the southern district . . .

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909