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Healthy Skepticism Library item: 15417

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Psaty BM.
Conflict of Interest, Disclosure, and Trial Reports
JAMA 2009 Apr 8; 301:(14):1477-1479
http://jama.ama-assn.org/cgi/content/extract/301/14/1477


Abstract:

When I was an assistant professor, my previous training had not prepared me for the unexpected attention that 2 articles, both from the same study, were to receive. One article provided evidence that abruptly stopping β-blockers might increase the risk of coronary events.1 The other suggested that, compared with the use of high-dose diuretics, which is now no longer recommended, the use of β-blockers might be associated with a lower risk of coronary events in hypertensive patients.2 While the news media’s coverage of the risk study was transient, the pharmaceutical industry had a more sustained interest in the other publication.

My family and I were invited to a first-class resort, where I presented the results at a sponsored conference. Although I lacked both the golf skills and the sense of entitlement to make the most of the holiday, the effort did result in a publication . . .

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909