Healthy Skepticism Library item: 15225

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Publication type: news

Internal Documents Suggest that Seroquel Data Were Not Presented Accurately
Clinical Psychology and Psychiatry: A Closer Look 2009 Mar 2
http://clinpsyc.blogspot.com/2009/03/internal-documents-suggest-that.html

Abstract:

A document dated March 9, 2000 titled “BPRS meta-analysis” shows that AstraZeneca, maker of the antipsychotic drug quetiapine (Seroquel), knew fully that its drug did not relieve schizophrenia symptoms to the same extent as its older, generic competitor haloperidol (Haldol). The document provides results of a meta-analysis, a statistical analysis that combines the results of several individual studies. The authors used the Brief Psychiatric Rating Scale (BPRS) as their main measure of efficacy. The BPRS rates a variety of psychiatric symptoms relevant to schizophrenia. More details on the BPRS can be seen here. A total of ten clinical trials were included in the meta-analysis, which variously compared Seroquel to placebo, Haldol, and several other antipsychotic medications. Four trials compared Seroquel to Haldol. Several subscales of the BPRS were included in the analysis…