Healthy Skepticism Library item: 14656

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: news

Mundy A.
Doctors Claim Glaxo Dismissed Worries on Avandia
The Wall Street Journal 2008 Nov 19
http://online.wsj.com/article/SB122705732777039555.html

Abstract:

Drug Maker Tried to Make Physician at Maryland Hospital Stop Talking About Concerns; Company Defends Its Effort

Full text:

Last year, after news broke that the diabetes drug Avandia was linked to a high risk of heart attacks, reports that the drug’s maker had tried to stifle safety questions from a prominent University of North Carolina researcher years earlier provoked a furor.

Now it turns out that the UNC researcher wasn’t alone in suggesting a tie to heart problems. A doctor from a small Maryland hospital linked Avandia to congestive heart failure in 2000, but the drug’s maker, GlaxoSmithKline PLC, rejected her warning and tried to make her stop talking about …

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909