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Healthy Skepticism Library item: 13718

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Cressey D.
Merck accused of disguising its role in research.
Nature 2008 Apr 17; 452:(7189):791
http://www.nature.com/news/2008/080416/full/452791b.html


Abstract:

Drug company used ghost-writers for papers published on Vioxx trials.

International drug giant Merck stands accused this week of manipulating research papers on one of its products published in medical journals.

Thousands of documents relating to Merck’s withdrawn painkiller rofecoxib (Vioxx) were made available as part of a legal action. They were reviewed by medical researchers paid by the litigants in the trial, which ended in 2006, and seem to show Merck’s extensive involvement in ghost-writing and ‘guest authorship’ of research and review papers. The results of the analysis are published this week in the Journal of the American Medical Association (JAMA).

By omitting the names – or downgrading the involvement – of drug-industry writers, and adding the names of academics who were not substantially involved in a paper, the industry’s role in research may be concealed. And doctors may be misled over the independence of the work…

Keywords:
Publication Types: News MeSH Terms: Authorship* Clinical Trials as Topic/economics Clinical Trials as Topic/ethics* Clinical Trials as Topic/legislation & jurisprudence* Drug Industry/economics Drug Industry/ethics* Drug Industry/legislation & jurisprudence* Humans Lactones/adverse effects* Sulfones/adverse effects* Substances: Lactones Sulfones rofecoxib

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909