Healthy Skepticism Library item: 13682

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Bruce S.
Cosmeceuticals for the attenuation of extrinsic and intrinsic dermal aging.
J Drugs Dermatol 2008 Feb; 7:(2):
http://www.ncbi.nlm.nih.gov/pubmed/18404867

Abstract:

Since the term “cosmeceutical” was coined over 2 decades ago, the number of products in this category that claim to combat dermal aging has grown dramatically. Topical retinoids remain the mainstay for treating photoaging given their proven efficacy in both clinical and histologic outcomes. In addition to retinoids, many other cosmeceutical agents are now available. The proliferation of products can cause confusion among consumers, who often ask their dermatologist for advice as to which antiaging products they should choose. Ideally, the antiaging claims of cosmeceutical formulations and their components should be demonstrated in controlled clinical trials. In order to provide appropriate recommendations to their patients, dermatologists must become familiar with the available data on currently marketed products and gain experience with antiaging regimens. This review discusses the efficacy of a number of currently marketed drug products with proven photoaging benefits and cosmeceutical products that claim similar benefits. Among the agents discussed are single-entity and combination products containing hydroquinones, retinoids, topical antioxidants, and minerals.

Keywords:
Publication Types: Review MeSH Terms: Administration, Topical Antioxidants/administration & dosage Antioxidants/therapeutic use Benzoquinones/administration & dosage Benzoquinones/therapeutic use Cosmetics/administration & dosage Cosmetics/therapeutic use* Dermatologic Agents/administration & dosage Dermatologic Agents/therapeutic use* Drug Combinations Humans Hydroquinones/administration & dosage Hydroquinones/therapeutic use Retinoids/administration & dosage Retinoids/therapeutic use Skin Aging/drug effects* Tretinoin/administration & dosage Tretinoin/therapeutic use Substances: Antioxidants Benzoquinones Cosmetics Dermatologic Agents Drug Combinations Hydroquinones Retinoids hydroquinone Tretinoin idebenone

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909