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Healthy Skepticism Library item: 13095

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: news

New debate into the efficacy of antidepressants
PM Live 2008 Feb 26
http://www.pmlive.com/index.cfm?showArticle=1&ArticleID=6522


Full text:

Antidepressant drugs are at the centre of a new debate about their efficacy, as mental health charities and the pharmaceutical industry deals with implications of a study published by the Public Library of Science (PLOS).

The meta-analysis conducted by the University of Hull (UH) indicates that antidepressants afford no significant clinical improvement to patients with mild depression.

The four drugs included in the study included GSK’s Paxil, Prozac (fluoxetine) manufactured by Eli Lilly and Co (ELC), Wyeth’s venlafaxine, Effexor, and Serzon (nefazodone) developed by Bristol-Myers Squibb (BMS).

Professor Irving Kirsch, lead researcher at UH psychology department, said: “Given these results, there seems little reason to prescribe antidepressant medication to any but the most severely depressed patients.”

“The difference in improvement between patients taking placebos and patients taking antidepressants is not very great. This means that depressed people can improve without chemical treatments.”

Coverage of the findings appeared in national media outlets on February 26 such as The Guardian, The Daily Telegraph, and BBC News with some stating that drugs such as Prozac ‘don’t work.’

Richard Ley of the Association of the British Pharmaceutical Industry (ABPI) warned the report could cause patients to stop taking antidepressants, and advised people to consult their doctors first.

UK mental health charity SANE echoed the ABPI’s concerns and said patients who stop taking antidepressants could experience severe bouts of rebound depression.

Marjorie Wallace, chief executive of SANE, said: “If validated, this research would mean that psychological therapies would be the only available treatments for the majority of people, but these do not work for everyone, particularly those with severe clinical depression.”

Professor Shelia Holmes, president of the Royal College of Psychiatrists, stressed that, “anyone currently taking antidepressants should first contact their own doctor before considering stopping their medication.”

But the reports findings have been welcomed by some quarters that believe the key to curing depression is talking therapies rather than prescription medications.

Paul Corry of mental health organisation, Rethink, said: “The doctors, the patients, and campaigners like us have been telling governments for years – spend NHS money on talking therapies and don’t just pour it into drugs.”

 

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
The blind faith which some men have in medicines illustrates too often the greatest of all human capacities - the capacity for self deception...
Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909