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Healthy Skepticism Library item: 13079

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Sismondo S.
How pharmaceutical industry funding affects trial outcomes: Causal structures and responses.
Soc Sci Med 2008 May Epub 2008 Ma; 66:(9):1909-14
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VBF-4S02PWH-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=23f3b59dd951d565e74c6c456f778350


Abstract:

Three recent systematic reviews have shown that pharmaceutical industry funding of clinical trials is strongly associated with pro-industry results. This article builds on those analyses, situating funding’s effects in the context of the ghost-management of research and publication by pharmaceutical companies, and the creation of social ties between those companies and researchers. There are multiple demonstrated causes of the association of funding and results, ranging from trial design bias to publication bias; these are all rooted in close contact between pharmaceutical companies and much clinical research. Given these points, most proposed measures to respond to this bias are too piecemeal to be adequate.

sismondo@queensu.ca

Keywords:
MeSH Terms: Bias (Epidemiology) Clinical Trials as Topic/economics* Clinical Trials as Topic/methods* Conflict of Interest Drug Industry/economics Drug Industry/organization & administration* Humans Periodicals as Topic

 

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...to influence multinational corporations effectively, the efforts of governments will have to be complemented by others, notably the many voluntary organisations that have shown they can effectively represent society’s public-health interests…
A small group known as Healthy Skepticism; formerly the Medical Lobby for Appropriate Marketing) has consistently and insistently drawn the attention of producers to promotional malpractice, calling for (and often securing) correction. These organisations [Healthy Skepticism, Médecins Sans Frontières and Health Action International] are small, but they are capable; they bear malice towards no one, and they are inscrutably honest. If industry is indeed persuaded to face up to its social responsibilities in the coming years it may well be because of these associations and others like them.
- Dukes MN. Accountability of the pharmaceutical industry. Lancet. 2002 Nov 23; 360(9346)1682-4.