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Healthy Skepticism Library item: 13079

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

 

Publication type: Journal Article

Sismondo S.
How pharmaceutical industry funding affects trial outcomes: Causal structures and responses.
Soc Sci Med 2008 May Epub 2008 Ma; 66:(9):1909-14
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VBF-4S02PWH-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=23f3b59dd951d565e74c6c456f778350


Abstract:

Three recent systematic reviews have shown that pharmaceutical industry funding of clinical trials is strongly associated with pro-industry results. This article builds on those analyses, situating funding’s effects in the context of the ghost-management of research and publication by pharmaceutical companies, and the creation of social ties between those companies and researchers. There are multiple demonstrated causes of the association of funding and results, ranging from trial design bias to publication bias; these are all rooted in close contact between pharmaceutical companies and much clinical research. Given these points, most proposed measures to respond to this bias are too piecemeal to be adequate.

sismondo@queensu.ca

Keywords:
MeSH Terms: Bias (Epidemiology) Clinical Trials as Topic/economics* Clinical Trials as Topic/methods* Conflict of Interest Drug Industry/economics Drug Industry/organization & administration* Humans Periodicals as Topic

 

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Cases of wilful misrepresentation are a rarity in medical advertising. For every advertisement in which nonexistent doctors are called on to testify or deliberately irrelevant references are bunched up in [fine print], you will find a hundred or more whose greatest offenses are unquestioning enthusiasm and the skill to communicate it.

The best defence the physician can muster against this kind of advertising is a healthy skepticism and a willingness, not always apparent in the past, to do his homework. He must cultivate a flair for spotting the logical loophole, the invalid clinical trial, the unreliable or meaningless testimonial, the unneeded improvement and the unlikely claim. Above all, he must develop greater resistance to the lure of the fashionable and the new.
- Pierre R. Garai (advertising executive) 1963