Healthy Skepticism Library item: 1247
Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.
Publication type: Journal Article
Baker CB, Johnsrud MT, Crismon ML, Rosenheck RA, Woods SW.
Quantitative analysis of sponsorship bias in economic studies of antidepressants.
Br J Psychiatry 2003 Dec; 183:498-506:
http://bjp.rcpsych.org/cgi/content/full/183/6/498
Abstract:
BACKGROUND: Concern is widespread about potential sponsorship influence on research, especially in pharmacoeconomic studies. Quantitative analysis of possible bias in such studies is limited. AIMS: To determine whether there is an association between sponsorship and quantitative outcomes in pharmacoeconomic studies of antidepressants. METHOD: Using all identifiable articles with original comparative quantitative cost or cost-effectiveness outcomes for antidepressants, we performed contingency table analyses of study sponsorship and design v. study outcome. RESULTS: Studies sponsored by selective serotonin reuptake inhibitor (SSRI) manufacturers favoured SSRIs over tricyclic antidepressants more than non-industry-sponsored studies. Studies sponsored by manufacturers of newer antidepressants favoured these drugs more than did non-industry-sponsored studies. Among industry-sponsored studies, modelling studies favoured the sponsor’s drug more than did administrative studies. Industry-sponsored modelling studies were more favourable to industry than were non-industry-sponsored ones. CONCLUSIONS: Pharmacoeconomic studies of antidepressants reveal clear associations of study sponsorship with quantitative outcome.
Keywords:
Antidepressive Agents/economics*
Antidepressive Agents/therapeutic use
Antidepressive Agents, Tricyclic/economics
Antidepressive Agents, Tricyclic/therapeutic use
Biomedical Research/standards*
Conflict of Interest
Cost-Benefit Analysis/methods
Drug Industry*
Ethics, Research
Financing, Organized/economics
Humans
Research Design/standards
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Serotonin Uptake Inhibitors/economics
Serotonin Uptake Inhibitors/therapeutic use
Treatment Outcome
