Healthy Skepticism Library item: 11917
Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.
Publication type: Journal Article
Kozyrskyj A, Raymond C, Racher A.
Characterizing early prescribers of newly marketed drugs in Canada: a population-based study.
Eur J Clin Pharmacol 2007 Jun; 63:(6):597-604
http://www.springerlink.com/content/j57055v8jlr31345/
Abstract:
BACKGROUND: The diffusion of innovations model proposes that early adopters of innovation influence others. This study was undertaken to determine if early prescribers and users of newly marketed drugs had different sociodemographic and professional characteristics as compared to majority and late users and prescribers.
METHODS: After market availability in Manitoba, Canada, of celecoxib, alendronate, clopiodogrel and pantoprazole, time to first prescriptions was determined. Early, majority and late adopters of the new drug were characterized by this diffusion time. The prescription, health and prescriber records were compared across adopter categories. The likelihood of being an early or late prescriber or user of the new medications according to patient demographic characteristics, physician factors (specialty and place of training) and neighborhood income was determined with polytomous logistic regression.
RESULTS: Celecoxib demonstrated a much more rapid uptake into routine use than the other drugs. More than 300 Manitoba physicians prescribed celecoxib within two weeks of market availability. Early prescribers of celecoxib were more likely than majority prescribers to be general practitioners (OR = 1.81, 95%CI: 1.40-2.35) and have hospital affiliations (OR = 1.35, 95%CI: 1.03-1.77). Early users of celecoxib were more likely than the majority to have arthritic conditions, have a high income and have paid out-of-pocket for their prescription. For alendronate, clopidogrel and pantoprazole, only prescription drug coverage predicted adopter category. Early prescribers of one new drug were not early prescribers of the other new drugs.
CONCLUSION: No common group of patients or physicians who were early prescribers or users of all four medications was described.
Anita Kozyrskyj
Email: kozyrsk@cc.umanitoba.ca
Keywords:
General practioners - Patient behavior - Polytomous logistic regression - Prescribing characteristics - Sociodemography
Publication Types:
Research Support, Non-U.S. Gov't
MeSH Terms:
2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use
Aged
Aged, 80 and over
Alendronate/therapeutic use
Attitude of Health Personnel
Data Collection
Diffusion of Innovation*
Drug Utilization/statistics & numerical data*
Drug Utilization/trends
Family Practice/statistics & numerical data
Family Practice/trends
Female
Humans
Insurance, Health, Reimbursement
Male
Manitoba
Middle Aged
Physician's Practice Patterns/statistics & numerical data*
Physician's Practice Patterns/trends*
Prescriptions, Drug/statistics & numerical data*
Pyrazoles/therapeutic use
Socioeconomic Factors
Sulfonamides/therapeutic use
Ticlopidine/analogs & derivatives
Ticlopidine/therapeutic use
Time Factors
Substances:
2-Pyridinylmethylsulfinylbenzimidazoles
Pyrazoles
Sulfonamides
pantoprazole
celecoxib
Ticlopidine
Alendronate
clopidogrel
