Healthy Skepticism Library item: 11558

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Publication type: Journal Article

Feuerstein GZ, Ruffolo RR.
Discontinued drugs in 2006: cardiovascular drugs translational medicine perspective.
Expert Opin Investig Drugs 2007 Sep; 16:(9):1315-26
http://www.expertopin.com/doi/abs/10.1517/13543784.16.9.1315

Abstract:

This perspective on discontinued cardiovascular drugs is the first in a series of papers on drugs dropped from clinical development in 2006. The compounds described in this perspective have been removed from development in various stages and for different reasons. This paper hereby provides a translational medicine perspective on these compounds based on information available through the Pharmaprojects pipeline database. In particular, potential gaps in the pipeline, due to a lack of biomarkers and translational medicine perspectives are emphasized.

Keywords:
Publication Types: Review MeSH Terms: Animals Biological Markers/analysis Cardiovascular Agents/adverse effects* Cardiovascular Agents/classification Cardiovascular Agents/standards* Drug Approval/methods Drug Industry/methods* Drug Industry/standards* Drug Industry/trends Drugs, Investigational/adverse effects Drugs, Investigational/classification Drugs, Investigational/standards Humans Substances: Biological Markers Cardiovascular Agents Drugs, Investigational