Healthy Skepticism Library item: 11389

Warning: This library includes all items relevant to health product marketing that we are aware of regardless of quality. Often we do not agree with all or part of the contents.

Publication type: Journal Article

Glasziou PP.
Publishing and reporting clinical trials
Med J Aust 2007 Sep 3; 187:(5):282
http://www.mja.com.au/public/bookroom/2007/glasziou/glasziou.html

Abstract:

THERE ARE NOW over 30 000 trials published each year (around 80 per day) – a rapid growth since the first randomised trial in the 1940s. Clinical trials are now deservedly influential in both clinical and policy decision making. Hence all clinicians should have a basic understanding of the why, what, and how of clinical trials.Interpreting and reporting clinical trials is an ideal starting point, and has been written by a mix of clinicians, statisticians and data managers with extensive experience in designing and running clinical trials…

Notes:

Review of:
Interpreting and reporting clinical trials. A guide to the CONSORT statement and the principles of randomised controlled trials. Anthony Keech, Val Gebski, Rhana Pike, editors. Sydney: MJA Books, 2007 (iv + 181 pp). ISBN 978 0 9775786 4 1.

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Far too large a section of the treatment of disease is to-day controlled by the big manufacturing pharmacists, who have enslaved us in a plausible pseudo-science...
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Some one will say, Is this all your science has to tell us? Is this the outcome of decades of good clinical work, of patient study of the disease, of anxious trial in such good faith of so many drugs? Give us back the childlike trust of the fathers in antimony and in the lancet rather than this cold nihilism. Not at all! Let us accept the truth, however unpleasant it may be, and with the death rate staring us in the face, let us not be deceived with vain fancies...
we need a stern, iconoclastic spirit which leads, not to nihilism, but to an active skepticism - not the passive skepticism, born of despair, but the active skepticism born of a knowledge that recognizes its limitations and knows full well that only in this attitude of mind can true progress be made.
- William Osler 1909