Healthy Skepticism Library item: 10120

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Publication type: Journal Article

Agrawal YK, Bhatt HG, Raval HG, Oza PM, Gogoi PJ.
Chirality - a new era of therapeutics.
Mini Rev Med Chem 2007 May; 7:(5):451-60
http://www.ingentaconnect.com/content/ben/mrmc/2007/00000007/00000005/art00001?token=00541e74ff2a53f7d32477582a2f4876753375686f4957275c277b422c40675276742544502e765f3c28

Abstract:

To develop the newer pharmaceuticals and to spur the strong growth, being a general property of ‘handedness’, chirality plays a major role. The Easson-Stedman principle shows the differences in the biological activity between enantiomers resulted from selective reactivity of one enantiomer with its receptor. It helps to improve the pharmacokinetic properties and to remove undesirable side effects by virtue of the unique activity of enantiomers. Racemic switching and marketing drug combinations are used as tools for drug life-cycle management and to redevelop racemic mixtures as single enantiomers.

Keywords:
Chirality; enantiomers; stereoselectivity; racemic switching; drug combination; pharmacokinetics PMID: 17504180 [PubMed - in process]